Fig. 5.

DNCdk5 but not DNCdk4 expression provides significant protection from endothelin-induced excitotoxic neuronal death in vivo. (a) Infarct volume of focal ischemic brains expressing GFP (n = 4), DNCdk4 (n = 4), or DNCdk5 (n = 4) measured 4 days after endothelin injection. Data are presented as mean ± SEM. * denotes significance (P < 0.01, DNCdk5- vs. GFP-expressing brains). There was also a significant difference (P < 0.05) between DNCdk4- and DNCdk5- but not between GFP- and DNCdk4-expressing brains (P > 0.05; ANOVA, Newman–Keuls Multiple Comparison Test). (b and c) Representative sections of the striatum from animals treated with (b) DNCdk5 or (c) GFP followed by endothelin injection. Sections are stained with cresyl violet