Table 3:

Percentage of patient allocation for the proposed PRO-ISO, PRO-CRM, and a nonparametric optimal benchmark over 7 dose-toxicity scenarios from Lee et al. (2020). The target C-DLT rate is 0.25, the target P-DLT rate is 0.35, and the sample sizes are $N=18$ and $N=40$ participants.

	$N=18$					$N=40$
Scenario 1
Probability of C-DLT	0.05	0.05	0.25	0.40	0.50	0.05	0.05	0.25	0.40	0.50
Probability of P-DLT	0.17	0.18	0.35	0.50	0.65	0.17	0.18	0.35	0.50	0.65
PRO-CRM	20.0	32.0	38.0	9.0	1.0	11.0	26.0	53.0	9.0	1.0
PRO-ISO	14.4	31.7	39.4	12.2	2.2	7.8	30.3	52.3	8.8	1.0
TITE-PRO-ISO	25.7	30.2	31.3	10.6	2.2	12.5	27.0	47.3	11.0	2.0
Scenario 2
Probability of C-DLT	0.05	0.25	0.40	0.55	0.70	0.05	0.25	0.40	0.55	0.70
Probability of P-DLT	0.10	0.15	0.35	0.50	0.65	0.10	0.15	0.35	0.50	0.65
PRO-CRM	25.0	45.0	23.0	6.0	1.0	17.0	55.0	24.0	3.0	1.0
PRO-ISO	20.6	49.4	24.4	5.0	0.6	13.8	60.8	23.0	2.3	0.3
TITE-PRO-ISO	26.8	43.0	23.5	6.1	1.1	15.8	54.3	25.0	4.3	0.8
Scenario 3
Probability of C-DLT	0.01	0.02	0.05	0.10	0.25	0.01	0.02	0.05	0.10	0.25
Probability of P-DLT	0.04	0.09	0.17	0.20	0.35	0.04	0.09	0.17	0.20	0.35
PRO-CRM	8.0	11.0	19.0	29.0	33.0	4.0	5.0	10.0	30.0	51.0
PRO-ISO	7.2	11.1	18.9	31.7	30.6	3.0	4.8	10.0	39.3	43.0
TITE-PRO-ISO	17.9	20.1	23.5	21.8	17.3	8.0	9.3	13.3	29.0	40.3
Scenario 4
Probability of C-DLT	0.02	0.05	0.10	0.25	0.40	0.02	0.05	0.10	0.25	0.40
Probability of P-DLT	0.09	0.17	0.20	0.35	0.50	0.09	0.17	0.20	0.35	0.50
PRO-CRM	13.0	19.0	31.0	29.0	8.0	6.0	9.0	30.0	47.0	8.0
PRO-ISO	10.6	16.7	31.1	32.8	8.9	5.3	8.8	34.3	43.8	8.0
TITE-PRO-ISO	20.7	25.1	26.8	20.1	7.8	9.3	13.3	29.0	38.3	10.3
Scenario 5
Probability of C-DLT	0.05	0.10	0.16	0.25	0.40	0.05	0.10	0.16	0.25	0.40
Probability of P-DLT	0.05	0.20	0.35	0.50	0.65	0.05	0.20	0.35	0.50	0.65
PRO-CRM	16.0	34.0	36.0	12.0	2.0	8.0	25.0	52.0	14.0	1.0
PRO-ISO	12.2	30.6	36.7	17.2	3.3	5.3	29.0	48.5	16.0	1.5
TITE-PRO-ISO	21.2	33.0	29.6	12.8	3.4	9.8	26.0	43.0	17.8	3.5
Scenario 6
Probability of C-DLT	0.05	0.18	0.20	0.25	0.40	0.05	0.18	0.20	0.25	0.40
Probability of P-DLT	0.17	0.35	0.50	0.65	0.80	0.17	0.35	0.50	0.65	0.80
PRO-CRM	36.0	45.0	16.0	3.0	0.0	24.0	57.0	17.0	2.0	0.0
PRO-ISO	30.6	42.8	20.0	5.6	1.1	23.0	55.5	19.0	2.5	0.3
TITE-PRO-ISO	33.0	42.5	18.4	5.6	1.1	21.8	52.0	20.8	4.5	0.8
Scenario 7
Probability of C-DLT	0.01	0.05	0.10	0.16	0.25	0.01	0.05	0.10	0.16	0.25
Probability of P-DLT	0.04	0.05	0.20	0.35	0.50	0.04	0.05	0.20	0.35	0.50
PRO-CRM	8.0	14.0	32.0	34.0	12.0	4.0	6.0	24.0	51.0	15.0
PRO-ISO	7.2	13.3	29.4	35.6	14.4	3.0	5.5	28.5	48.3	14.8
TITE-PRO-ISO	17.9	20.7	28.5	22.3	11.2	8.0	9.8	24.8	40.0	17.5