Fig. 7.

Effects of PI3-K activity on shear-dependent phase 2 response in chondrocytes. Cells were transfected with pBJ M·p110^* (constitutively active PI3-K), pBJ M·p110·UR (Δkinase mutant), or pBJ-null vector, subjected to static conditions or laminar flow (20 dyn/cm²) for 48 h, and NQO1 enzyme activity (A) and total GSH levels (B) were determined. Data are relative to null-transfected static cultures (n = 4, *, P < 0.01 with respect to static controls; ‡, P < 0.05 with respect to null-transfected shear)