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. 2005 Sep 15;102(39):13944–13949. doi: 10.1073/pnas.0506654102

Fig. 1.

Fig. 1.

Bcl2 protein expression is inversely correlated with miR-15a and miR-16-1 miRNAs expression in CLL patients. (A) The unique site of complementarity miR::mRNA is conserved in human and mouse and is the same for all four human members of the family. The sites of target mutagenesis are indicated (3′M1 and 3′M2). (B) In CLL patients the levels of Bcl2 protein are inversely correlated with miR-15a and miR-16-1 expression. Five different CLL cases are presented, and the normal cells were pools of CD5+ B lymphocytes. The T cell leukemia Jurkat was used as control for Bcl2 protein expression. For normalization we used β-actin. The numbers represent normalized expression on miRNACHIP. ND, not determined. (C) The coefficients of correlation in the full set of 26 samples is ≈95% for both miR-15a and miR-16-1. The normalized Bcl2 expression is on abscissa vs. miR-15a (Left) and miR-16-1 (Right) levels by miRNA chip on ordinates. ACT, β-actin.