Figure 1.

Alcohol-drinking patterns and anxiety-like behaviors in P and NP rats. Upper panel: Ethanol intake (7% for 3 days, 10% for 3 days, and 12% for 3 days) was measured by the 2-bottle free choice paradigm in P and NP rats. Values represent the mean ± SEM of 6 rats in each group. Lower panel: The effects of voluntary ethanol intake on open- and closed-arm activities of P and NP rats in the EPM test. Values represent the mean ± SEM of 5–6 rats in each group. *P < 0.001 versus respective controls.