Figure 10.

The effect of PKA inhibitor infusion into the CeA on ethanol intake and anxiety-like behaviors in NP rats. Upper panel: The alcohol-drinking patterns (7 and 9% ethanol) and the effect of Rp-cAMP infusion into the CeA (last 3 days of 9% ethanol intake) on alcohol intake in NP rats. Values represent the mean ± SEM of 7–8 rats in each group. Lower panel: The effect of PKA inhibitor infusion (0.5 μl of 40 nmol of Rp-cAMP or aCSF once daily for 3 days) and alcohol drinking on open- and closed-arm activities of NP rats in the EPM. Values represent the mean ± SEM of 7–8 rats in each group. ^#P < 0.01, *P < 0.001 versus NP rats infused with aCSF.