Figure 5.
MMP expression (A) and densitometric quantification (B) in pulmonary arteries. Homogenates of lung tissue were examined from MCT-challenged animals receiving STI571 at 50 mg/kg/d, as compared with controls and nontreated MCT animals. Western blots for the pro and active forms of MMP-2 and MMP-9 (A) and densitometric quantification normalized to GAPDH (B) are shown. *P < 0.05 versus control; †P < 0.05 versus MCT at day 42.