Figure 6.

Increased PDGFRβ expression/phosphorylation in MCT-induced pulmonary hypertension. Western blot analysis was used to assess expression of PDGFRβ and PDGFRβ phosphorylation (P-PDGFRβ) in rat lungs from controls and animals treated with MCT (14 days), MCT (28 days), MCT (42 days), and MCT (42 days)/STI571. Immunoblots are representative of 4 individual lungs from each group, showing identical results. Quantification of PDGFRβ and PDGFRβ phosphorylation is shown in the bar graphs. PDGFRβ and PDGFRβ phosphorylation are normalized to GAPDH. *P < 0.05 versus control; ^†P < 0.05 versus MCT at day 28; ^‡P < 0.05 versus MCT at day 42.