Figure 8.

Increased PDGFRβ signaling (ERK1/2 phosphorylation) in MCT-induced pulmonary hypertension. Western blot analysis was used to assess expression of ERK1/2 phosphorylation (P-ERK1/2) in rat lungs from controls and animals treated with MCT (14 days), MCT (28 days), MCT (42 days), and MCT (42 days)/STI571. Immunoblots are representative of 4 individual lungs from each group, showing identical results. Quantification of ERK1/2 phosphorylation is shown in the bar graph. ERK1/2 phosphorylation is normalized to ERK1.