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Macrophage RCT in SR-BI–knockout mice. SR-BI–/– mice and wild-type littermates were injected intraperitoneally with [3H]cholesterol-labeled J774 foam cells in 2 independent experiments and results pooled for analysis (n = 11 per group). (A) [3H]cholesterol in plasma, liver, and feces. (B) Cholesterol mass and [3H]cholesterol lipoprotein profile of pooled plasma samples drawn 24 hours after injection of J774 cells subjected to FPLC analysis. *P < 0.05; **P < 0.01.
