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. 2025 Aug 15;104(33):e43197. doi: 10.1097/MD.0000000000043197

Table 8.

Top 20 keywords with the most frequencies concerning the research of epigenetics in cancers.

Rank Keywords Frequency TLS Rank Keywords Frequency TLS
1 DNA methylation 12,146 31,628 11 Hypermethylation 2583 8758
2 Expression 11,414 31,127 12 Differentiation 2530 6679
3 Cancer 9964 25,611 13 Activation 2477 7070
4 Epigenetics 6762 18,308 14 Identification 2460 7048
5 Methylation 6652 18,845 15 Transcription 2406 6475
6 Gene-expression 5781 12,995 16 Apoptosis 2373 7084
7 Gene 4083 11,932 17 Mutations 2359 5852
8 Cells 3192 9081 18 Epigenetic regulation 2283 5766
9 Breast-cancer 2781 7525 19 Protein 2216 5969
10 Chromatin 2648 6597 20 Growth 2122 6594

TLS = total link strength.