Table 3.
Univariate binary logistic regression of PTDM risk factors in KTx patients.
| Variable | N | OR | 95% CI | P-value |
|---|---|---|---|---|
| Dialysis modality before KTx | 130 | |||
| HD | – | – | ||
| PD | 0.80 | 0.25, 2.26 | .7 | |
| PREE | 0.68 | 0.10, 2.83 | .6 | |
| Gender | 130 | |||
| Female | – | – | ||
| Male | 0.83 | 0.35, 1.96 | .7 | |
| Age (yr) | 130 | 1.04 | 1.01, 1.08 | .019 |
| BMI kg/m2 | 130 | 1.12 | 1.01, 1.25 | .044 |
| BMI ≥ 30 | 130 | |||
| 0 | – | – | ||
| 1 | 2.26 | 0.71, 6.63 | .15 | |
| Number | 130 | |||
| 1st | – | – | ||
| 2nd and 3rd KTx | 0.38 | 0.02, 2.17 | .4 | |
| Pre-transplant dialysis time (mo) | 128 | 0.99 | 0.98, 1.00 | .3 |
| Number of HLA mismatches | 130 | 1.08 | 0.77, 1.52 | .7 |
| Cause of ESRD | 130 | |||
| GN | – | – | ||
| ADPKD | 1.88 | 0.37, 7.73 | .4 | |
| IN | 0.83 | 0.12, 3.65 | .8 | |
| Not known | 1.00 | 0.14, 4.51 | >.9 | |
| HN/IschN | 2.92 | 0.91, 9.09 | .065 | |
| Other (a/HUS) | 3.00 | 0.55, 14.2 | .2 | |
| Induction use (basiliximab/anti-thymocyte globulin) | 130 | |||
| 0 | – | – | ||
| 1 | 2.00 | 0.78, 5.83 | .2 | |
| Tacrolimus use (0), Cyclosporin use (1) | 130 | |||
| 0 | – | – | ||
| 1 | 0.44 | 0.10, 1.40 | .2 | |
| 2-wk cumulative methylprednisolon dose | 130 | 0.73 | 0.34, 1.46 | .4 |
| AR | 130 | |||
| 0 | – | – | ||
| 1 | 1.88 | 0.25, 10.2 | .5 | |
| DGF | 130 | |||
| 0 | – | – | ||
| 1 | 0.57 | 0.16, 1.67 | .3 | |
| CSC 1 mo after KTx (mg/dL) | 130 | 0.91 | 0.48, 1.50 | .7 |
| eGFR 4p MDRD 1 mo after KTx (mL/min/1.73 m2) | 130 | 1.00 | 0.98, 1.01 | .9 |
| Duration of hospitalization after KTx (days) | 130 | 1.01 | 0.95, 1.06 | .8 |
| CMV infection | 130 | |||
| 0 | – | – | ||
| 1 | 0.79 | 0.12, 3.33 | .8 | |
| UTI | 130 | |||
| 0 | – | – | ||
| 1 | 1.93 | 0.67, 5.23 | .2 | |
| WIT (min) | 129 | 1.03 | 0.98, 1.09 | .2 |
| CIT (min) | 128 | 1.00 | 1.00, 1.00 | .073 |
| HbA1c before KTx (mmol/mol) | 125 | 3.69 | 1.26, 12.0 | .022 |
| HbA1c > 5.7 mmol/mol | 125 | |||
| 0 | – | – | ||
| 1 | 4.45 | 1.48, 13.5 | .007 | |
| Glycemia before KTx (mg/dL) | 123 | 1.04 | 1.01, 1.08 | .021 |
| Glycemia before KTx > 99 (mg/dL) | 130 | |||
| 0 | – | – | ||
| 1 | 3.92 | 1.25, 12.1 | .017 | |
| Insulin level before KTx (µU) | 123 | 1.02 | 0.97, 1.07 | .4 |
| HOMA-IR Index before KTx | 119 | 1.08 | 0.92, 1.27 | .3 |
| HOMA over the normal range before KTx > 2 | 119 | |||
| 0 | – | – | ||
| 1 | 1.76 | 0.69, 4.36 | .2 | |
| QUICKI under the normal range before KTx < 0.34 | 119 | |||
| 0 | – | – | ||
| 1 | 2.16 | 0.77, 5.77 | .13 | |
| TyG index | 122 | 1.68 | 0.72, 4.04 | .2 |
| Homocysteine before KTx (µmol) | 125 | 1.00 | 0.97, 1.03 | .8 |
| Homocysteine before KTx (µmol) over the normal range ≥ 15 µmol | 130 | |||
| 0 | – | – | ||
| 1 | 1.75 | 0.60, 6.39 | .3 | |
| Cholesterol before KTx (mg/dL) | 127 | 1.00 | 0.99, 1.01 | .6 |
| Triglyceride before KTx (mg/dL) | 127 | 1.00 | 1.00, 1.01 | .4 |
| HDL cholesterol before KTx (mg/dL) | 126 | 1.00 | 0.97, 1.03 | >.9 |
| LDL cholesterol before KTx (mg/dL) | 126 | 1.00 | 0.99, 1.01 | .6 |
| Uric acid before KTx (mg/dL) | 124 | 0.89 | 0.69, 1.14 | .4 |
| C-peptide before KTx (ng/mL) | 128 | 1.03 | 0.95, 1.11 | .5 |
| Albumin before KTx (g/L) | 127 | 0.76 | 0.23, 2.39 | .6 |
ADPKD = autosomal dominant polycystic kidney disease; AR = acute rejection; BMI = body mass index; CI = confidence interval; CIT = cold ischemia time; CSC = creatinine serum concentration; DGF = delayed graft function; eGFR CKD-EPI = estimated glomerular filtration rate and chronic kidney disease epidemiology collaboration; eGFR 4p MDRD = estimated glomerular filtration rate and 4-point modification of diet in renal disease formula; ESRD = end-stage renal disease; HBA1c = glycosylated hemoglobin, Type A1c; HD = hemodialysis; HDL = high-density lipoprotein; HLA = human leucocytes antigens; IschN = ischemic nephropathy; HOMA-IR Index = homeostatic model assessment of insulin resistance index; HUS = hemolytic uremic syndrome; KTx = kidney transplantation; N = number of patients; OR = odds ratio; PD = peritoneal dialysis; PREE = preemptive kidney transplantation; QUICKI = quantitative insulin-sensitivity check index; TyG index = triglycerides and glucose index; WIT = warm ischemia time.