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. 2025 Aug 15;104(33):e43879. doi: 10.1097/MD.0000000000043879

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Copyright © 2025 the Author(s). Published by Wolters Kluwer Health, Inc.

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Figure 7. — Construction and analysis of PPI networks. (A) Construct the PPI network of DEGs using STRING online database and utilize Cytoscape software for analysis. (B) CLUSTER was used to identify the central gene. (C) MCC was used to identify the central gene. (D) DMNC was used to identify the central gene. (E) EPC was used to identify the central gene. (F) Seven core genes (Stat3, Lag3, Mki67, Fcgr2b, Gzmb, Ccr5, Epcam) were obtained by merging using Venn diagrams. DEGs = differentially expressed genes, PPI = protein–protein interaction, STRING = search tool for the retrieval of interacting genes.