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. 2025 Aug 15;104(33):e43879. doi: 10.1097/MD.0000000000043879

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Copyright © 2025 the Author(s). Published by Wolters Kluwer Health, Inc.

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Figure 8. — Expression heatmap of core genes and CTD disease association analysis. (A) Heatmap of core gene expression in disease (GSM8018656–8658) and control (GSM8018653–8655) samples. GZMB showed the most significant upregulation (P < .01). Red: high expression; green: low expression. (B) CTD analysis linking GZMB to toxicological phenotypes such as inflammation, necrosis, hyperplasia, and clinical symptoms including headache and dizziness, reinforcing its role in toxic encephalopathy. CTD = comparative toxicogenomics database, GZMB = Granzyme B.