Table 3.
Multivariable ordinal logistic regression analysis of factors associated with tumor differentiation grade.
| Variable | β | OR (95% CI) | P-value |
|---|---|---|---|
| Imaging parameters | |||
| CT-ECV (per 5% increase) | 0.62 (0.15) | 1.86 (1.39–2.49) | <.001 |
| ΔHU (tumor) (per 10 HU increase) | 0.41 (0.18) | 1.51 (1.06–2.14) | .022 |
| Serum biomarkers | |||
| CEA (per 10 ng/mL increase) | 0.33 (0.11) | 1.39 (1.12–1.72) | .003 |
| CA19-9 (per 50 U/mL increase) | 0.28 (0.09) | 1.32 (1.11–1.58) | .002 |
| NLR (per 1 unit increase) | 0.45 (0.13) | 1.57 (1.21–2.03) | <.001 |
| Clinical confounders | |||
| TNM Stage (III–IV vs I–II) | 0.87 (0.22) | 2.39 (1.55–3.68) | <.001 |
| Tumor size (per 1 cm increase) | 0.21 (0.10) | 1.23 (1.01–1.50) | .041 |
Bold values indicate statistical significance.
CA125 = carbohydrate antigen 125, CA19-9 = carbohydrate antigen 19-9, CEA = carcinoembryonic antigen, CI = confidence interval, CT-ECV = computed tomography-derived extracellular volume fraction, NLR = neutrophil-to-lymphocyte ratio, OR = odds ratio, TNM = Tumor, Node, Metastasis Classification System.