Table 4.
Receiver operating characteristic analysis of individual and combined parameters for predicting poor differentiation.
| Model | AUC (95% CI) | Sensitivity (%) | Specificity (%) | cutoff | P-value |
|---|---|---|---|---|---|
| Individual parameters | |||||
| CT-ECV | 0.82 (0.75–0.88) | 78.3 | 76.6 | ≥34.5% | – |
| CEA | 0.73 (0.66–0.80) | 71.7 | 68.2 | ≥18.7 ng/mL | .021 |
| CA19-9 | 0.71 (0.63–0.78) | 67.4 | 72.5 | ≥47.2 U/mL | .015 |
| NLR | 0.76 (0.69–0.83) | 73.9 | 74.1 | ≥3.8 | .038 |
| Combined models | |||||
| CT-ECV + CEA | 0.85 (0.79–0.91) | 82.6 | 79.3 | – | .003 |
| CT-ECV + NLR | 0.87 (0.81–0.93) | 84.8 | 81.6 | – | .001 |
| Comprehensive model* | 0.91 (0.86–0.96) | 89.1 | 86.4 | – | <.001 |
AUC = area under the curve, CA19-9 = carbohydrate antigen 19-9, CEA = carcinoembryonic antigen, CI = confidence interval, CT-ECV = computed tomography-derived extracellular volume fraction, NLR = neutrophil-to-lymphocyte ratio.
*
Comprehensive model includes: CT-ECV, CA19-9, and NLR.