Table 4.
Details of the IVs used for MR analysis (causal effect of BE on COPD).
| SNP | Exposure | Outcome | MRPRESSO | |||||
|---|---|---|---|---|---|---|---|---|
| Beta | EAF | SE | Beta | EAF | SE | RSSobs | P value | |
| rs10031416 | 0.315 | 0.012 | 0.068 | 0.057 | 0.010 | 0.058 | 8.40E−03 | 1 |
| rs10039754 | 0.084 | 0.550 | 0.015 | 0.019 | 0.426 | 0.013 | 7.97E−04 | .969 |
| rs10104032 | 0.093 | 0.375 | 0.016 | 0.043 | 0.426 | 0.012 | 1.16E−03 | .171 |
| rs10207635 | 0.137 | 0.135 | 0.022 | 0.032 | 0.089 | 0.020 | 3.28E−04 | 1 |
| rs10224888 | 0.073 | 0.638 | 0.016 | 0.010 | 0.598 | 0.012 | 6.61E−06 | 1 |
| rs10484245 | 0.132 | 0.088 | 0.027 | 0.035 | 0.072 | 0.022 | 4.54E−04 | 1 |
| rs10982622 | 0.085 | 0.462 | 0.015 | 0.009 | 0.535 | 0.012 | 3.51E−04 | 1 |
| rs10986761 | 0.085 | 0.289 | 0.017 | 0.048 | 0.269 | 0.013 | 1.57E−03 | .228 |
| rs11040802 | 0.084 | 0.236 | 0.018 | 0.002 | 0.197 | 0.014 | 4.80E−05 | 1 |
| rs11761457 | 0.099 | 0.208 | 0.019 | 0.009 | 0.257 | 0.013 | 1.94E−06 | 1 |
| rs11766872 | 0.079 | 0.283 | 0.017 | 0.006 | 0.293 | 0.013 | 4.78E−06 | 1 |
| rs11792928 | 0.098 | 0.295 | 0.017 | 0.012 | 0.269 | 0.013 | 5.36E−04 | 1 |
| rs12207319 | 0.075 | 0.309 | 0.016 | 0.000 | 0.221 | 0.014 | 7.22E−05 | 1 |
| rs12474870 | 0.088 | 0.189 | 0.019 | 0.002 | 0.151 | 0.016 | 5.32E−05 | 1 |
| rs1247942 | 0.096 | 0.405 | 0.015 | 0.003 | 0.358 | 0.012 | 6.19E−05 | 1 |
| rs12595438 | 0.122 | 0.092 | 0.026 | 0.021 | 0.096 | 0.019 | 6.69E−05 | 1 |
| rs12607067 | 0.143 | 0.074 | 0.029 | 0.055 | 0.085 | 0.020 | 1.65E−03 | 1 |
| rs12712508 | 0.075 | 0.356 | 0.016 | 0.016 | 0.430 | 0.012 | 6.82E−05 | 1 |
| rs12987825 | 0.082 | 0.288 | 0.017 | 0.020 | 0.416 | 0.013 | 8.46E−04 | 1 |
| rs13085889 | 0.089 | 0.275 | 0.017 | 0.019 | 0.203 | 0.014 | 8.41E−05 | 1 |
| rs13195040 | 0.162 | 0.115 | 0.025 | 0.036 | 0.095 | 0.022 | 2.99E−03 | .684 |
| rs1346563 | 0.081 | 0.285 | 0.017 | 0.007 | 0.250 | 0.015 | 2.55E−04 | 1 |
| rs143384 | 0.079 | 0.401 | 0.015 | 0.016 | 0.364 | 0.012 | 5.41E−05 | 1 |
| rs16862777 | 0.087 | 0.276 | 0.017 | 0.001 | 0.299 | 0.012 | 7.16E−05 | 1 |
| rs16966166 | 0.130 | 0.100 | 0.025 | 0.006 | 0.217 | 0.015 | 6.23E−05 | 1 |
| rs17114682 | 0.109 | 0.118 | 0.023 | 0.035 | 0.159 | 0.016 | 5.51E−04 | 1 |
| rs17451754 | 0.103 | 0.135 | 0.022 | 0.029 | 0.149 | 0.018 | 1.62E−03 | 1 |
| rs1828682 | 0.072 | 0.479 | 0.015 | 0.013 | 0.365 | 0.013 | 2.49E−05 | 1 |
| rs1868915 | 0.089 | 0.587 | 0.015 | 0.030 | 0.506 | 0.012 | 4.16E−04 | 1 |
| rs1876389 | 0.078 | 0.551 | 0.015 | 0.012 | 0.535 | 0.012 | 1.43E−05 | 1 |
| rs205262 | 0.082 | 0.264 | 0.017 | 0.052 | 0.219 | 0.014 | 1.91E−03 | .057 |
| rs2597301 | 0.114 | 0.689 | 0.016 | 0.007 | 0.664 | 0.012 | 4.11E−04 | 1 |
| rs2861695 | 0.107 | 0.806 | 0.019 | 0.012 | 0.807 | 0.016 | 7.36E−07 | 1 |
| rs2877766 | 0.071 | 0.424 | 0.015 | 0.022 | 0.416 | 0.012 | 2.07E−04 | 1 |
| rs288186 | 0.079 | 0.646 | 0.016 | 0.002 | 0.716 | 0.013 | 1.09E−04 | 1 |
| rs3072 | 0.110 | 0.367 | 0.016 | 0.022 | 0.417 | 0.012 | 1.12E−04 | 1 |
| rs31260 | 0.083 | 0.269 | 0.017 | 0.009 | 0.347 | 0.013 | 1.63E−10 | 1 |
| rs4317189 | 0.083 | 0.687 | 0.016 | 0.008 | 0.667 | 0.012 | 8.50E−07 | 1 |
| rs459078 | 0.085 | 0.281 | 0.017 | 0.029 | 0.235 | 0.013 | 4.01E−04 | 1 |
| rs4646607 | 0.080 | 0.418 | 0.015 | 0.003 | 0.500 | 0.012 | 3.76E−05 | 1 |
| rs4655026 | 0.072 | 0.574 | 0.015 | 0.022 | 0.455 | 0.012 | 2.04E−04 | 1 |
| rs4938330 | 0.089 | 0.205 | 0.018 | 0.001 | 0.236 | 0.013 | 1.03E−04 | 1 |
| rs4947741 | 0.080 | 0.284 | 0.017 | 0.007 | 0.270 | 0.013 | 4.55E−06 | 1 |
| rs6032949 | 0.085 | 0.208 | 0.019 | 0.009 | 0.232 | 0.013 | 2.70E−08 | 1 |
| rs622217 | 0.091 | 0.482 | 0.015 | 0.008 | 0.432 | 0.012 | 3.30E−04 | 1 |
| rs6874700 | 0.071 | 0.364 | 0.016 | 0.022 | 0.330 | 0.012 | 9.18E−04 | 1 |
| rs7187365 | 0.111 | 0.823 | 0.020 | 0.012 | 0.823 | 0.015 | 2.15E−11 | 1 |
| rs739414 | 0.101 | 0.742 | 0.018 | 0.011 | 0.757 | 0.013 | 5.11E−04 | 1 |
| rs7537908 | 0.089 | 0.205 | 0.019 | 0.014 | 0.251 | 0.013 | 2.09E−05 | 1 |
| rs7613818 | 0.073 | 0.517 | 0.015 | 0.026 | 0.590 | 0.012 | 3.56E−04 | 1 |
| rs769657 | 0.085 | 0.331 | 0.016 | 0.053 | 0.316 | 0.012 | 2.02E−03 | <.06 |
| rs7720419 | 0.090 | 0.379 | 0.016 | 0.014 | 0.319 | 0.012 | 2.14E−05 | 1 |
| rs773109 | 0.078 | 0.336 | 0.016 | 0.011 | 0.292 | 0.013 | 3.75E−04 | 1 |
| rs7772622 | 0.072 | 0.559 | 0.015 | 0.019 | 0.593 | 0.012 | 1.24E−04 | 1 |
| rs8044476 | 0.103 | 0.150 | 0.021 | 0.002 | 0.176 | 0.015 | 1.70E−04 | 1 |
| rs8067516 | 0.113 | 0.148 | 0.022 | 0.009 | 0.135 | 0.019 | 1.14E−05 | 1 |
| rs8102046 | 0.092 | 0.556 | 0.015 | 0.010 | 0.627 | 0.012 | 9.63E−08 | 1 |
BE = Barrett’s esophagus, COPD = chronic obstructive pulmonary disease, IVs = instrumental variables, MR = Mendelian randomization, MR-PRESSO = Mendelian Randomization Pleiotropy RESidual Sum and Outlier, SNP = single nucleotide polymorphism.