Table 1.

Intra-run and inter-run accuracy and precision for TAK-981 in human K₂EDTA plasma.

Run Number	LLOQ 0.100 ng/mL	LQC 0.300 ng/mL	MQC 30.0 ng/mL	HQC 75.0 ng/mL
1	0.0938	0.309	32.0	79.6
	0.0972	0.325	31.9	77.6
	0.0951	0.309	30.9	75.3
	0.104	0.317	32.9	77.5
	0.0958	0.288	30.8	78.8
	0.0991	0.307	32.2	77.6
Intra-run Mean	0.0975	0.309	31.8	77.7
Intra-run S.D.	0.00367	0.0124	0.804	1.46
Intra-run %CV	3.8	4.0	2.5	1.9
Intra-run %RE	−2.5	3.0	6.0	3.6
n	6	6	6	6
2	0.0940	0.342	28.9	76.2
	0.0929	0.256	30.2	73.3
	0.108	0.287	30.1	72.7
	0.0854	0.291	29.5	74.8
	0.102	0.289	30.0	71.1
	0.0890	0.311	29.5	77.2
Intra-run Mean	0.0952	0.296	29.7	74.2
Intra-run S.D.	0.00838	0.0286	0.494	2.28
Intra-run %CV	8.8	9.7	1.7	3.1
Intra-run %RE	−4.8	−1.3	−1.0	−1.1
n	6	6	6	6
3	0.109	0.323	31.1	76.7
	0.107	0.346*	31.6	74.1
	0.113	0.325	33.4	76.9
	0.109	0.320	32.8	76.6
	0.112	0.318	31.2	74.8
	0.105	0.334	31.1	75.3
Intra-run Mean	0.109	0.328	31.9	75.7
Intra-run S.D.	0.00299	0.0106	0.991	1.16
Intra-run %CV	2.7	3.2	3.1	1.5
Intra-run %RE	9.0	9.3	6.3	0.9
n	6	6	6	6
Inter-run Mean	0.101	0.311	31.1	75.9
Inter-run S.D.	0.00817	0.0223	1.27	2.18
Inter-run %CV	8.1	7.2	4.1	2.9
Inter-run %RE	1.0	3.7	3.7	1.2
n	18	18	18	18

Note: *: Deviation from nominal > 15%; value included in statistics.

%CV: percent coefficient of variation; %RE: percent relative error; HQC: high-quality control; LLOQ: lower limit of quantitation; LQC: low-quality control; MQC: medium-quality control; n: number; S.D.: standard deviation.