Table 4.

TAK-981 stability in human K₂EDTA plasma after five freeze/thaw cycles.

Run Number	LQC 0.300 ng/mL	HQC 75.0 ng/mL	Dil 20 QC 1,000 ng/mL
4	0.286	68.1	931
Freeze at 20°C and	0.272	71.9	887
thaw in an ice bath	0.300	68.8	850
	0.305	72.3	900
Mean	0.291	70.3	892
S.D.	0.0149	2.13	33.5
%CV	5.1	3.0	3.8
%RE	−3.0	−6.3	−10.8
n	4	4	4
Freeze at 70°C and	0.296	69.9	929
thaw in an ice bath	0.287	67.9	888
	0.297	66.8	900
	0.288	67.0	875
Mean	0.292	67.9	898
S.D.	0.00523	1.42	23.1
%CV	1.8	2.1	2.6
%RE	−2.7	−9.5	−10.2
n	4	4	4

Note: %CV: percent coefficient of variation; %RE: percent relative error; Dil 20 QC: 20-fold dilution QC; HQC: high-quality control; LQC: low-quality control; n: number; S.D.: standard deviation.