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. 2025 Aug 21;16:1590. doi: 10.1007/s12672-025-03393-3

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© The Author(s) 2025

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 1 — Transcriptome-wide analysis revealed abnormal gene expression after knockdown METTL3-14 in PANC-1 cell line. (A) Hierarchical clustering heat map showing correlation between METTL3-14-knockdown (siMETTL3_14 rep1/2/3) and siC (siC rep1/2/3) samples based on FPKM value of all expression genes. (B) Volcano plot showing all differential expressed genes (DEGs) between METTL3_14-knockdown and siC samples using DESeq2. FDR ≤ 0.05 and FC (fold change) ≥ 2 or ≤ 0.5. (C) Principal component analysis (PCA) of siMETTL3_14 and siC samples in PANC-1 cell line based on FPKM value of all Differentially expressed genes (DEGs). The ellipse for each group is the confidence ellipse. (D) Heatmap showing expression profile of all significant DEGs between METTL3_14-knockdown and siC samples. (E) Bar plot showing the top10 most enriched GO biological process terms of the up-regulated DEGs. (F) Bar plot showing the top10 most enriched GO biological process terms of the down-regulated DEGs. (G) Bar plot exhibited the most enriched KEGG pathways results of the up-regulated DEGs. (H) Bar plot exhibited the most enriched KEGG pathways results of the down-regulated DEGs