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. 2025 Aug 21;16:1590. doi: 10.1007/s12672-025-03393-3

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© The Author(s) 2025

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 3 — Peak analysis of m6A methylation in METTL3 knockout. (A) Venn diagram shows the overlap of two sets of data m6A peak. (B) Barplot shows the distribution proportion of overlap peak. (C) Enrichment analysis of m 6 A -overlap Peak and input reads around translation start and stop codons and TSS and TTS.Reads count were normalized in a ± 1000 bp window around translation start and stop codons and TSS and TTS. (D) Motif analysis showing the top 3 preferred bound motifs of METTL3_14 using HOMER software. (E) Bar plot exhibited the most enriched GO biological process results of METTL3_14 overlap Peak genes. (F) Bar plot exhibited the most enriched KEGG pathways process results of the overlap peak genes