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Combination of mutations in different checkpoint genes cause synergistic increases in the GCR rate. The GCR rates of the indicated mutant strains were determined as described under Materials and Methods. The values for fold induction were calculated by dividing the GCR rate of the indicated mutant strain by the GCR rate of the wild-type (WT) strain. The GCR rates are from Tables 2, 4, and 8.
