Table 7.
Effect of pds1Δ and rad53Δ mutations on GCR rates
| Relevant genotype | Wild type
|
pds1Δ
|
rad53Δ sml1Δ
|
|||
|---|---|---|---|---|---|---|
| Strain | GCR rate × 1010 | Strain | GCR rate × 1010 | Strain | GCR rate × 1010 | |
| Wild type | 3615 | 3.5 (1)* | 3729 | 670 (190)* | 3749 | 95 (27)* |
| mad2Δ | 4584 | 5.6 (1.6) | 4585 | 660 (189) | ND | |
| rad24Δ | 3723 | 40 (11)* | 4573 | 1,300 (371)‡ | 4587 | 140 (40) |
| rfc5-1 | 3727 | 660 (189)* | 4617 | 1,400 (400)‡ | 4586 | 500 (143) |
| sgs1Δ | 3813 | 77 (22)† | 4569 | 390 (111)§ | 4588 | 460 (131) |
| mec1Δ sml1Δ | 3735 | 680 (194)* | 3823 | 3,200 (914)* | 3753 | 1,000 (286)* |
| tel1Δ | 3731 | 2.0 (0.6)* | 3821 | 14,000 (4,000) | 3767 | 750 (214)* |
| dun1Δ | 3739 | 730 (208)* | 4570 | 2,000 (571)‡ | ND | |
| rad53Δ sml1Δ | 3749 | 95 (27)* | 4571 | 490 (140)§ | NA | |
| chk1Δ | 3745 | 130 (37)* | 4572 | 830 (237)§ | 3751 | 230 (64)* |
| mre11Δ | 3633 | 2,200 (629)* | 4592 | 18,000 (5,143) | ND | |
( ) indicates the GCR rate relative to the wild-type GCR rate. ND, not determined; NA, not applicable.
*
Data from Myung et al. (22).
†
Data from Myung et al. (64).
‡
Significant difference compared to the GCR rate of the pds1 strain at the 95% confidence interval (Student's t test).
§
No significant difference compared to the GCR rate of the pds1 strain at the 95% confidence interval (Student's t test). Note that the wild-type GCR rate is 3.5 × 10−10.