Table 1.
Genotype | Spleen
|
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---|---|---|---|---|---|---|---|---|---|---|
Thymus
|
T cells, %
|
B cells, %
|
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Cellularity, ×107 | CD4−CD8−, % | CD4+CD8−, % | CD4−CD8+, % | CD4+CD8+, % | Cellularity, ×106 | CD4+CD8−, % | CD4−CD8+, % | Marginal zone | Follicular | |
Wild type | 16 ± 2 | 3 ± 0.4 | 7 ± 1 | 2 ± 0.3 | 88 ± 4 | 70 ± 21 | 21 ± 2 | 16 ± 2 | 4.1 ± 0.3 | 46 ± 7 |
nfkb1−/− | 17 ± 1 | 2 ± 0.3 | 8 ± 2 | 2 ± 0.3 | 89 ± 4 | 92 ± 17 | 13 ± 3 | 11 ± 3 | 1.7 ± 0.3 | 37 ± 6 |
c-rel−/− | 15 ± 2 | 2 ± 0.4 | 6 ± 1 | 3 ± 0.2 | 86 ± 4 | 76 ± 18 | 19 ± 2 | 11 ± 1 | 3.7 ± 0.7 | 46 ± 9 |
nfkb1−/− c-rel−/− | 17 ± 2 | 3 ± 0.2 | 6 ± 1 | 2 ± 0.3 | 87 ± 5 | 77 ± 28 | 18 ± 3 | 13 ± 2 | 1.7 ± 0.6 | 29 ± 7 |
The mean ± SD were based upon the analysis of six mice of each genotype.