Table 1:
Activity at rest
| NHP G | NHP I | Total | ||||
|---|---|---|---|---|---|---|
| pre-MPTP | post-MPTP | pre-MPTP | post-MPTP | pre-MPTP | post-MPTP | |
| Number of Units | 92 | 82 | 88 | 109 | 180 | 191 |
| Firing rate (mean ± SD) | 68.6 ± 22.8 | 37.2 ± 21.2 | 69.3 ± 26.6 | 18.4 ± 12.7 | 69.0 ± 24.7 | 26.5 ± 19.2 |
| Coefficient of variation of ISI (mean ± SD) | 1.1 ± 0.4 | 1.3 ± 0.5 | 1.1 ± 0.5 | 1.4 ± 0.7 | 1.1 ± 0.5 | 1.4 ± 0.6 |
| Proportion of spikes in burst (mean ± SD) | 0.10 ± 0.11 | 0.20 ± 0.17 | 0.11 ± 0.12 | 0.20 ± 0.20 | 0.10 ± 0.12 | 0.20 ± 0.19 |
| Normalized Intra-burst firing rate (mean ± SD) | 4.7 ± 1.3 | 6.0 ± 6.4 | 4.4 ± 1.5 | 6.8 ± 9.7 | 4.6 ± 1.4 | 6.5 ± 8.4 |
| Oscillation at rest (units) | 47 (51%) | 33 (40%) | 28 (32%) | 23 (21%) | 75 (42%) | 56 (29%) |
| Theta (4-7.9 Hz) | 0 | 3 (8%) | 0 | 1 (4%) | 0 | 4 (6%) |
| Alpha (8-12 Hz) | 1 (2%) | 4 (11%) | 1 (3%) | 0 | 2 (2%) | 4 (6%) |
| Beta (12.5-30 Hz) | 27 (49%) | 24 (65%) | 5 (16%) | 17 (65%) | 32 (37%) | 41 (65%) |
| Low Beta (12.5-20 Hz) | 0 | 23 (92%) | 3 (60%) | 5 (29%) | 3 (9%) | 28 (67%) |
| High Beta (20.5-30 Hz) | 27 (100%) | 2 (8%) | 2 (40%) | 12 (71%) | 29 (91%) | 14 (33%) |
| Gamma (30.5-100 Hz) | 27 (49%) | 6 (16%) | 25 (81%) | 8 (31%) | 52 (60%) | 14 (22%) |
| Ramping of firing rate at rest (units) | 79 (86%) | 74 (90%) | 81 (92%) | 106 (97%) | 160 (89%) | 180 (94%) |
| Positive slope (units) | 32 (41%) | 33 (45%) | 35 (43%) | 50 (47%) | 67 (42%) | 83 (46%) |
| Negative slope (units) | 47 (59%) | 41 (55%) | 46 (57%) | 56 (53%) | 93 (58%) | 97 (54%) |
Underlined numbers indicate significant difference between pre- and post-MPTP (Wilcoxon rank sum test; single line p<0.05, double line p<0.01). Bold numbers indicate significant difference between pre- and post-MPTP (Residual analysis following chi-square test, p<0.05)