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. Author manuscript; available in PMC: 2005 Nov 1.
Published in final edited form as: Invest Ophthalmol Vis Sci. 2005 Sep;46(9):3426–3434. doi: 10.1167/iovs.05-0344

Figure 4.

Figure 4

Dose-dependent effect of H2O2 exposure on apoptosis in RPE with different levels of SOD2. An equal number of RPE cells derived from WT (○), HET (▵), and HEMI (▪) mice were exposed to various concentrations of H2O2 for 1 hour and recultured in normal medium for 16 hours, and apoptosis was determined by a cell-death–detection ELISA kit. Cells from HET mice showed greater apoptosis than did those from WT or HEMI mice at all levels of H2O2 exposure. A higher level of SOD2 (HEMI) protected the RPE cells from apoptosis. Data are expressed as the mean ± SEM (n = 4 to 7). *P < 0.05 compared with those of WT.