Table I.
Comparison of 5′-NT Levels in Various Tissues
| Tissue activity |
APCP-inhibitable 5′-NT activity |
Non-APCP 5′-NT |
|
|---|---|---|---|
| Cd73 +/+ | Cd73 −/− | Pooleda | |
|
|
nmol/h/mg ± SEM
|
nmol/h/mg ± SEM
|
|
| Colon | 1,523 ± 116 | 9 ± 3b | 237 ± 41 |
| Lung | 248 ± 56 | 14 ± 4b | 73 ± 4 |
| Heart | 171 ± 64 | 1 ± 0.1b | 33 ± 5 |
| Muscle | 33 ± 5 | 6 ± 0.9b | undetectable |
| Brain | 891 ± 128 | 10 ± 6b | 89 ± 16 |
| Liver | 347 ± 26 | 1 ± 0.1b | 40 ± 4 |
| Kidney | 799 ± 158 | 6 ± 4b | 90 ± 5 |
a
Non-APCP inhibitable 5′-NT activity, pooled from both Cd73 +/+ and Cd73 −/− animals.
b
Indicates significantly different than wild type (P < 0.001) for n = 7–9 mice per group.