Fig. 2.

Experiment 1a PR and SEFL. A) Timecourse of active lever responding across PR testing. In females, adolescent and adult control groups differed, so analysis was conducted separately for adult and adolesce Ctx-A treatment groups. In adolescent treated females, active lever responding was significantly lower in shocked (n=9) rats compared to controls (n=10). In adult treated females, responding was similar between control (n=9) and shocked rats (n=8). In males, responding did not differ between adolescent control (n=10) and shocked rats (n=9) or between adult control (n=4) and shocked (n=7). B) Breakpoints from PR testing. In females, breakpoints were highest in rats given control treatment in adolescence compared to all other groups. In males, breakpoints were similar across all groups. C) Ctx-C SEFL testing following either Ctx-A extinction or no extinction. In non-extinguished rats, adolescent (n=7; f=3; m=4) and adult (n=6; f=3; m=3) shocked rats exhibited significantly greater freezing compared to controls (n=11; f=5; m=6). In contrast, in the extinguished group, freezing was significantly greater in adult shocked (n=6; f=3; m=3) rats compare to controls (n=10; f=5; m=5) but freezing did not differ between controls and adolescent shocked rats (n=5; f=3; m=2). (Data shown as means with SEM; *: different from controls, p<0.05; f: females; m: males).