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. Author manuscript; available in PMC: 2026 Aug 7.
Published in final edited form as: Cell. 2025 Aug 7;188(21):6044–6063.e24. doi: 10.1016/j.cell.2025.07.016

Figure 2: Right cervical vagotomy alleviates CAC manifestations in mice with lung (LLC) or orthotopic pancreatic (KPC) cancer.

Figure 2:

A. Schematic outlining the treatment groups assessed. B. Representative photos of mice from each experimental group. LLC tumors outlined with dashed red lines. C. Weight change in mice with and without vagotomy, with and without cancer. Vagotomy or sham surgeries were performed on day −5, cancer cells or PBS were injected on day 0. N=56 (8 animals per group). Analysis by RMANOVA with Tukey HSD. D. Left: representative photomicrographs of right gastrocnemius muscle sections stained with wheat germ agglutinin (WGA) in green. Scale bars 100 μm. Center: quantification right gastrocnemius muscle fiber cross-sectional area. WT controls are the same for each cancer cohort. Right: Grip strength of WT, KPC, and LLC mice with and without vagotomy. WT controls are the same for each cancer cohort. N=48 (8 animals per group). Statistical analysis by ANOVA with Tukey Post-Hoc. E. Survival curve showing survival duration in cancer-injected mice with vagotomy or sham procedure. Statistical significance by Peto’s Log Rank Test. For all box plots, dots represent data collected from unique mice. For all tests, * represents p<0.05, ** represents p<0.01, *** represents p<0.001, **** represents p<0.0001. See also Movie S1, Figure S2.