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. Author manuscript; available in PMC: 2026 Aug 7.
Published in final edited form as: Cell. 2025 Aug 7;188(21):6044–6063.e24. doi: 10.1016/j.cell.2025.07.016

Figure 3: Right cervical vagotomy attenuates behavioral abnormalities and enhances chemotherapy response in lung (LLC) or orthotopic pancreatic (KPC) cancer.

Figure 3:

A. Spontaneous motion over 15 minutes in open field assay and socialization in three chamber social assay. WT controls are the same for each cancer cohort. N=48 (8 animals per group). B. Quantification of daily food consumption from cage top feeder. WT controls are the same for each cancer cohort. N=48 (8 animals per group). C. Survival curve showing longitudinal survival of LLC- or KPC-injected mice receiving sham surgeries or vagotomy with or without chemotherapy. Statistical significance by Peto’s Log Rank Test with Bonferroni correction for multiple comparisons (6-fold). D. Weight changes in LLC or KPC bearing-mice which received sham surgeries or vagotomy with or without chemotherapy. N=64 (8 animals per group). Analysis by RMANOVA with Tukey HSD. E. Tumor burden measurements at time of sacrifice in tumor bearing-mice which received sham surgeries or vagotomy with or without cisplatin chemotherapy. N=64, 8 mice per group. F-G. Impacts of hexamethonium, atropine, or PBS treatment in KPC or LLC mice and WT controls on (F) weight loss and (G) survival. N=56, 8 per condition. Statistical significance for survival by Peto’s Rank-Log test with 3x Bonferroni correction. Statistical analysis by ANOVA with Tukey Post-Hoc unless otherwise stated. For all box plots, dots represent data collected from unique mice. For all tests, * represents p<0.05, ** represents p<0.01, *** represents p<0.001, **** represents p<0.0001. See also Figure S2–S4.