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. Author manuscript; available in PMC: 2026 Aug 7.
Published in final edited form as: Cell. 2025 Aug 7;188(21):6044–6063.e24. doi: 10.1016/j.cell.2025.07.016

Figure 7: Transcutaneous vagal block for 30 minutes a day rescues CAC.

Figure 7:

A. Photo of mouse with tLFACb flexible electrode patch. B. Weight changes presented as mean percent initial weight plus or minus SEM. Cancer injections performed on day 0. Red arrows indicate daily tLFACb therapy start date. N=64, 8 animals per group; statistical analysis by RMANOVA with Tukey HSD. C. Spontaneous motion over 15 minutes in open field assay. N=40, 8 animals per group. D. Socialization in three chamber social assay. N=40, 8 animals per group. E. Quantification of mean daily food consumption from a trough placed on the cage floor. N=40, 8 animals per group. F. Quantification of right gastrocnemius muscle fiber cross-sectional area. N=40, 8 animals per group. G. Grip strength of WT, KPC, and LLC mice with and without tLFACb. N=40, 8 animals per group. H. Number of falls by WT, KPC, and LLC mice with and without tLFACb during hanging wire test. N=40, 8 animals per group. I. Quantification of root mean square of vagal ENG signal 12 hours after administration of 30-minute tLFACb therapy or sham. N=25 mice, 5 per group. J. Survival curve for KPC or LLC mice receiving tLFACb therapy or with sham device with or without chemotherapy; significance by Peto’s Log Rank Test with Bonferroni correction for multiple comparisons (6-fold). For all box plots, dots represent data collected from unique mice. For all tests, * represents p<0.05, ** represents p<0.01, *** represents p<0.001, **** represents p<0.0001. Statistical analysis by ANOVA with Tukey Post-Hoc unless otherwise stated. See also Figure S7.