Figure 4.

IL-12Rβ1-deficient mice are not responsive to exogenous IL-12. C57BL/6J (WT) and IL-12Rβ1 deficient (12Rβ1) mice were infected intranasally with VSV. At day 3 pi, the animals were euthanized and their CNS collected and homogenized. The amount of virus in the CNS homogenates was determined by plaque assay. These data are presented as the geometric mean (n=6) ± geometric error and represent 2 individual experiments. Treatment groups compared using a two-tailed t-test (* = p < 0.05).