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Replicative lifespan of NHF (A) and PrEC (B) overexpressing human SIRT proteins. The replicative histories of control and SIRT-overexpressing cells are shown as the growth curves, where the cumulative PDs are plotted to the days after retroviral transduction. All NHF-derived and PrEC-derived cells ceased to proliferate at 47 and at 13 PDs, respectively, with the characteristic features of cellular senescence such as enlarged and flat cell morphology and positive SA-β-gal staining.
