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Schematic diagram showing the genomic organization of members of the apo L gene family (apo L1–L6) on human chromosome 22q12.3. Linkage of schizophrenia to chromosome 22q11–22q13 has been reported and was replicated in several independent studies. Note the proximity of the apo L cluster to the loci for velocardiofacial syndrome (VCFS) and catechol-o-methyltransferase (COMT) (see text).
