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The Wnt-NLK pathway inhibits the activity of Myb family of proteins by two different mechanisms. The Wnt-NLK pathway inhibits A-Myb activity by blocking the interaction between A-Myb and CBP and inducing the methylation of histone H3-K9. In contrast, the Wnt-NLK pathway inhibits c-Myb activity by inducing proteasome-dependent c-Myb degradation.
