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APP−/− fibroblasts exhibit deficits in calcium signaling resembling PS1−/− cells. (a) Representative BK-evoked calcium signals from APP−/− fibroblasts and controls. The amplitude of calcium signals is diminished in APP−/− cells (b) but increased in Chinese hamster ovary cells overexpressing APP (c). Data are mean ± SE of 6 experiments per condition. *, P < 0.01.
