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The calcium deficits in APP−/− cells can be rescued by transfection with constructs containing the AICD. (a) Schematic illustration of the APP constructs used for transfections. (b) Rescue of the calcium impairments in APP−/− cells was achieved after transfection with constructs containing an intact AICD or AICD alone, but not by constructs lacking this domain. Data are mean ± SE of 8 experiments per condition. *, P < 0.05 relative to APP−/− cells.
