Table 1.
Antischistosomal activity and toxicity of clocinizine compared to standard drugs.
| Compounds | S. mansoni | Cells | SI | |||
|---|---|---|---|---|---|---|
| Male | Female | |||||
| EC50 (µM) | EC90 (µM) | EC50 (µM) | EC90 (µM) | EC50 (µM) | ||
| Clocinizine | 4.6 ± 0.7 | 5.9 ± 0.9 | 4.6 ± 0.7 | 5.9 ± 0.9 | > 200 | > 43 |
| 1 | > 50 | > 50 | > 50 | > 50 | ND | ND |
| 2 | > 50 | > 50 | > 50 | > 50 | ND | ND |
| Praziquantel | 0.9 ± 0.01 | 1.1 ± 0.01 | 1.0 ± 0.01 | 1.2 ± 0.01 | > 200 | > 200 |
| Doxorubicin | ND | ND | ND | ND | 10.4 ± 3.5 | ND |
ND: Not determined. SI: Selectivity index, calculated as the ratio of the CC50 value in Vero cells to the EC50 value in S. mansoni (SI = CC50/EC50). Data represent the mean ± S.D. from at least three independent experiments performed in triplicate.