Table 2.
Summary of the GO analyses of the ubiquitinated proteins unique to GlcSph exposure
| PANTHER cellular component | Homo sapiens (REF) | Found | Expected | Fold enrichment | Raw p-value | FDR |
|---|---|---|---|---|---|---|
| Intermediate filament cytoskeleton | 51 | 5 | 0.13 | 39.58 | 2.62E−07 | 3.34E−05 |
| Cytoskeleton | 751 | 9 | 1.86 | 4.84 | 9.01E−05 | 2.07E−03 |
| Ribosomal subunit | 80 | 4 | 0.20 | 20.19 | 5.51E−05 | 1.29E−02 |
| PANTHER molecular function | ||||||
| Misfolded protein binding | 16 | 3 | 0.4 | 75.69 | 1.34E−05 | 4.57E−04 |
| Heat shock protein binding | 33 | 3 | 0.8 | 36.7 | 9.58E−05 | 2.91E−03 |
| ATP binding | 41 | 4 | 0.10 | 39.39 | 4.57E−06 | 1.66E−04 |
| PANTHER protein class | ||||||
| Hsp70 chaperone | 15 | 3 | 0.4 | 80.74 | 1.13E−05 | 2.21E−03 |
| Tubulin | 24 | 4 | 0.6 | 50.46 | 3.99E−05 | 3.91E−03 |
| Ribosomal protein | 177 | 5 | 0.44 | 11.40 | 8.53E−05 | 5.57E−03 |
| PANTHER pathway | ||||||
| Serine glycine biosynthesis | 6 | 2 | 0.1 | >100 | 1.66E−04 | 3.79E−03 |
| Parkinson disease | 101 | 4 | 0.25 | 15.99 | 1.31E−04 | 4.21E−03 |