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. 2025 Aug 21;15:30765. doi: 10.1038/s41598-025-16546-9

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© The Author(s) 2025

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 2 — Neutralizing IL-18 decreases IFN-γ and IL-4 production in the myometrium and the decidua. (A) Schematic representation of low-dose LPS (1 µg) and IL-18 nAb administration to pregnant mice. (B, C) Flow cytometric analysis of intercellular IL-4 and IFN-γ production in the indicated immune cells in the decidua (B) and myometrium (C) of pregnant mice at Gd 9.5. *p < 0.05, **p < 0.01; Mann–Whitney U-test. Gd, gestational day; LPS, lipopolysaccharide; ns, not significant.