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. 2025 Aug 21;15:30765. doi: 10.1038/s41598-025-16546-9

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© The Author(s) 2025

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Fig. 3 — Neutralizing IL-18 canceled STAT1 and STAT6 activation induced by low-dose LPS administration. (A) Immunofluorescence staining of decidua and myometrium on Gd 9.5. The samples were prepared as shown in Fig. 2A. Upper lane, LPS (−) and IL-18 nAb (−); middle lane, LPS (+) and IL-18 nAb (−); lower lane, LPS (+) and IL-18 nAb (+). The dotted lines indicate the border between the decidua (dec) and the myometrium (myo). Blue indicated DAPI, green indicates pSTAT6, and red indicated pSTAT1. White bar, 50 μm. (B) Percentage of pSTAT1-positive and pSTAT6-positive cells in the decidua and myometrium. ****p < 0.0001; Mann–Whitney U-test. Gd, gestational day; LPS, lipopolysaccharide.