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. 2025 Aug 21;15:30765. doi: 10.1038/s41598-025-16546-9

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© The Author(s) 2025

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 4 — Injection of IL-4 and IFN-γ improves LPS-induced miscarriage. (A) Schematic representation of the experimental setup. Recombinant (r)IFNγ was administered daily from Gd 5.5 and rIL-4 from Gd 8.5 until Gd 12.5. (B) Abortion rate was evaluated at 13.5. n = 12 for LPS (-), IL-18 nAb (-), rIL-4 (-), rIFN-γ (-); n = 12 for LPS (+), IL-18 nAb (-), rIL-4 (-), rIFN-γ (-); n = 12 for LPS (+), IL-18 nAb (+), rIL-4 (-), rIFN-γ (-); n = 13 for LPS (+), IL-18 nAb (+), rIL-4 (+), rIFN-γ (-); n = 12 for LPS (+), IL-18 nAb (+), rIL-4 (-), rIFN-γ (+); n = 13 for LPS (+), IL-18 nAb (+), rIL-4 (+), rIFN-γ (+) ****p < 0.0001; one-way ANOVA analysis followed by Turkey’s post hoc test. Gd, gestational day; LPS, lipopolysaccharide.