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Inhibition of de novo actin polymerization does not disassemble VACs in IFN-γ-treated cells. Confluent T84 monolayers were preincubated for 40 h with IFN-γ followed by 15-min incubation with either G-actin sequestering drug latrunculin B (5 μM) or vehicle. Note that inhibition of de novo actin polymerization by sequestration of G-actin does not cause disassembly of VACs in IFN-γ-treated cells (arrows). Scale bar, 10 μm.
