Table 1.

Molecular Docking parameters. AutoDock 4.2 molecular Docking software was used for semi-flexible Docking between DT and P-gp. The tested protein was treated as rigid while keeping the ligand flexible. P-gp: P-glycoprotein; DT- diosmetin.

Size of girid box	100 × 100 × 100
Girid points spaced	0.375
Algorithm	Lamarckian genetic algorithm (LGA)
Genetic algorithm runs	30
Population size	300 inviduals
Maximum numer of Energy evaluations	250,000
Gegenerations	150,000
Mutation rate	0.02
Crossover rate	0.80