Table 4.

Comparisons of the changes from baseline of the King’s Health questionnaire scores between the daytime and nighttime dosing groups (n = 109).

Variables	4 weeks			12 weeks
	Daytime (n = 52)†	Nighttime (n = 57)†	p‡	Daytime (n = 40)†	Nighttime (n = 46)†	p‡
Frequency (0–3)	− 0.7 ± 1.3**	− 0.9 ± 1.2**	0.56	− 1.0 ± 1.1**	− 1.1 ± 1.2**	0.76
Nocturia (0–3)	− 0.7 ± 1.0**	− 0.7 ± 1.1**	0.95	− 1.0 ± 1.1**	− 0.9 ± 1.2**	0.92
Urgency (0–3)	− 0.6 ± 1.2**	− 0.7 ± 1.3**	0.50	− 0.8 ± 1.3**	− 0.5 ± 1.3*	0.35
Urge incontinence (0–3)	− 0.8 ± 1.2**	− 0.7 ± 1.1**	0.84	− 0.6 ± 1.3**	− 0.8 ± 1.2**	0.59
Stress Incontinence (0–3)	− 0.6 ± 1.1**	− 0.5 ± 0.9**	0.44	− 0.6 ± 0.9**	− 0.5 ± 1.0**	0.58
Nocturnal enuresis (0–3)	− 0.2 ± 0.7**	− 0.1 ± 0.8	0.27	− 0.2 ± 0.6	− 0.2 ± 0.8	0.70
Intercourse incontinence (0–3)	− 0.1 ± 0.5	− 0.1 ± 0.5	0.97	0.0 ± 0.4	0.0 ± 0.2	0.71
Waterworks infections (0–3)	− 0.1 ± 0.3**	− 0.1 ± 0.3**	0.97	− 0.5 ± 1.2*	− 0.5 ± 0.8**	0.86
Bladder pain (0–3)	− 0.5 ± 1.0**	− 0.5 ± 1.0	0.78	− 0.5 ± 1.0**	− 0.2 ± 0.8	0.16
General health perceptions (0–100)	− 12 ± 25**	− 5 ± 24	0.15	− 13 ± 27**	− 14 ± 26**	0.86
Incontinence impact (0–100)	− 18 ± 38**	− 20 ± 35**	0.80	− 19 ± 38**	− 24 ± 37**	0.62
Role limitations (0–100)	− 14 ± 29**	− 21 ± 30**	0.23	− 19 ± 24**	− 26 ± 38**	0.34
Physical limitations (0–100)	− 26 ± 40**	− 20 ± 32**	0.35	− 37 ± 37**	− 25 ± 40**	0.20
Social limitations (0–100)	− 10 ± 34*	− 9 ± 26*	0.86	− 17 ± 28**	− 18 ± 34**	0.81
Personal relationships (0–100)	− 5 ± 23	− 2 ± 12	0.52	− 10 ± 26	− 3 ± 19	0.31
Emotions (0–100)	− 17 ± 25**	− 6 ± 19	0.006	− 17 ± 28**	− 13 ± 26**	0.48
Sleep/energy (0–100)	− 18 ± 31**	− 18 ± 28**	0.96	− 19 ± 32**	− 31 ± 28**	0.09
Severity measures (0–100)	− 10 ± 21**	− 12 ± 22**	0.70	− 14 ± 23**	− 13 ± 21**	0.84

^†By paired t test. *p < 0.05, **p < 0.01.

^‡By paired t test.

Changes are calculated as the subtraction of pre-treatment values from post-treatment values, and expressed as the mean ± standard deviation.