Table 2.
MRI measures
| LB group | HC group | W-value/ χ²-value, p-value | |
|---|---|---|---|
| Global WMSA, log10 | 3.46 (0.32) | 3.26 (0.27) | W = 897, p = < 0.001 |
| NbM volume, mm3 | 220 (77) | 242 (60) | W = 377, p = 0.009 |
| Absolute cholinergic WMSA | |||
| Total cholinergic WMSA, log10 | 3.02 (0.40) | 2.76 (0.29) | W = 971, p < 0.001 |
| Cholinergic WMSA in cingulate pathway, log10 | 2.38 (0.49) | 1.79 (0.62) | W = 970, p < 0.001 |
| Cholinergic WMSA in External capsule, log10 | 3.02 (0.40) | 2.76 (0.29) | W = 970, p < 0.001 |
| Cholinergic WMSA in the frontal lobe, log10 | 1.51 (1.00) | 0.57 (0.76) | W = 872, p < 0.001 |
| Cholinergic WMSA in the temporal lobe, log10 | 1.17 (0.65) | 0.87 (0.60) | W = 892, p < 0.001 |
| Cholinergic WMSA in the parietal lobe, log10 | 2.09 (0.75) | 1.68 (0.62) | W = 863, p = 0.001 |
| Cholinergic WMSA in the occipital lobe, log10 | 1.97 (0.43) | 1.83 (0.40) | W = 696, p = 0.222 |
| Cholinergic WMSA in insula, log10 | 0.90 (0.72) | 0.34 (0.69) | W = 865, p = 0.001 |
| Proportion Cholinergic WMSA | |||
| Proportion total cholinergic WMSA | 0.37 (0.09) | 0.31 (0.13) | W = 817, p = 0.008 |
| Proportion cholinergic WMSA in cingulate pathway | 0.09 (0.06) | 0.04 (0.05) | W = 896, p < 0.001 |
| Proportion cholinergic WMSA in external capsule pathway | 0.37 (0.10) | 0.31 (0.13) | W = 817, p = 0.008 |
| Proportion cholinergic WMSA in Frontal lobe | 0.14 (0.37) | 0.06 (0.15) | W = 803, p = .012 |
| Proportion cholinergic WMSA in Temporal lobe | 0.88 (0.30) | 0.75 (0.39) | W = 649, p = 0.513 |
| Proportion cholinergic WMSA in Parietal lobe | 0.77 (0.31) | 0.82 (0.34) | W = 599, p = 0.957 |
| Proportion cholinergic WMSA in Occipital lobe | 0.79 (0.37) | 0.80 (0.30) | W = 478, p = 0.165 |
| Proportion cholinergic WMSA in Insula | 0.57 (0.53) | 0.01 (0.79) | W = 715, p = 0.149 |
| Mean diffusivity | |||
| MD in Cingulate pathway | 9.97 × 10−4 (1.08 × 10−4) | 9.40 × 10−4 (6.27 × 10−5) | W = 887, p < 0.001 |
| MD in External capsule pathway | 1.18 × 10−3 (1.21 × 10−4) | (1.12 × 10−3) (9.25 × 10−5) | W = 895, p < 0.001 |
| MD in the non-cholinergic WM | 8.38 × 10−4 (5.46 × 10−5) | 8.12 × 10−4 (2.09 × 10−5) | W = 864, p = 0.001 |
Median and IQR are reported in the table. Global WMSA and the absolute measures of WMSA in the cholinergic system were log10 transformed. Global WMSA, NbM volume and the absolute cholinergic WMSA measures were adjusted for age and eTIV. For “proportion total cholinergic WMSA”, “proportion cholinergic WMSA in the cingulate pathway”, and “proportion cholinergic WMSA in the external capsule pathway”, the raw cholinergic WMSA measures were divided by global WMSA. For the four lobar proportion cholinergic WMSA measures and insula WMSA, raw cholinergic WMSA measures were divided by each lobe or insula WMSA. Proportional cholinergic measures and MD in the white matter pathways were adjusted for age.
HC Healthy controls, LB Lewy body, MD Mean diffusivity, NbM Nucleus basalis of Meynert, WM white matter, WMSA White matter signal abnormalities.