Table 2.
Clinicopathological characteristics in the training cohort: non-RAIT failure vs. RAIT failure.
| Characteristic | Training(n = 122) | P value | |
|---|---|---|---|
| Non- RAIT failure (n = 72) |
RAIT failure (n = 50) |
||
| Age, mean ± SD, years | 39.74 ± 11.83 | 38.82 ± 13.07 | 0.688¶ |
| Gender | 0.245§ | ||
| Male | 21 (29.17) | 20 (40.00) | |
| Female | 51 (70.83) | 30 (60.00) | |
| CI | 0.711§ | ||
| Positive | 40 (55.56) | 30 (60.00) | |
| Negative | 32 (44.44) | 20 (40.00) | |
| ETE | 0.763§ | ||
| Positive | 17 (23.61) | 13 (26.00) | |
| Negative | 55 (76.39) | 37 (74.00) | |
| Diameter, median ± interquartile range, cm | [1.45(0.93, 2.20)] | [1.65(1.28, 3.00)] | 0.063‖ |
| CLN metastasis | 0.238§ | ||
| N0 | 6 (8.33) | 1 (2.00) | |
| NX | 66 (91.67) | 49 (98.00) | |
| LLN metastasis | 0.001§ | ||
| N0 | 37 (51.39) | 8 (16.00) | |
| NX | 35 (48.61) | 42 (84.00) | |
| Number of LLN metastasis, median ± interquartile range | [0.00(0.00, 4.00)] | [6.50(3.00, 12.25)] | 0.001‖ |
| I-131 dosage, median ± interquartile range, mCi | [150(140, 150)] | [150(150, 150)] | 0.002‖ |
| Time from surgery to RAIT, median ± interquartile range, months | [4.00(3.00, 5.00)] | [3.00(2.75, 5.25)] | 0.738‖ |
| Previous thyroid disease | 0.174§ | ||
| Positive | 28 (38.89) | 13 (26.00) | |
| Negative | 44 (61.11) | 37 (74.00) | |
| Multifocality of lesions | 0.707§ | ||
| Positive | 43 (59.72) | 32 (64.00) | |
| Negative | 29 (40.28) | 18 (36.00) | |
| Tg before RAIT, median ± interquartile range, IU/ml | [1.10(0.08, 4.23)] | [12.92(0.44, 37.42)] | 0.001‖ |
| Maximum diameter of metastatic LLN, median ± interquartile range, mm | [0.00(0.00, 14.00)] | [10.00(10.00, 25.25)] | 0.001‖ |
| TGAb before RAIT, median ± interquartile range, IU/ml | [0.82(0.24, 4.87)] | [0.62(0.18, 8.37)] | 0.963‖ |
Data expressed as n (%), unless otherwise stated. CI, capsular invasion; CLN, central lymph node; ETE, extrathyroidal extension; LLN, lateral neck lymph node; RAIT, radioactive iodine therapy; Tg, thyroglobulin; TGAb, anti-thyroglobulin antibodies. ¶ By the Independent samples t-test. § By the Chi-square test. ‖ By the Mann–Whitney U test.