Effect of a caspase inhibitor (A, Z VAD fmk or B, Z LEHD fmk) on the % survival within 12h PT of transected and neighboring, untransected (inset, A, B) B104 cells.
B104 cells were preincubated for 60min, transected, and maintained for 12h PT in control medium, (A, B unfilled squares) or in control medium containing a broad caspase inhibitor (Z VAD fmk; A, filled circles), or a specific Caspase-9 inhibitor (Z LEHD fmk; B, filled circles). The viability of transected and neighboring, untransected cells (insets in A, B) was assessed morphologically at 2, 4, 8, and 12h PT.