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. 2025 Aug 21;8:537. doi: 10.1038/s41746-025-01911-9

Table 1.

Correlation between predicted age and chronological age

Predictor Corr. coefficent p-value
MethylDetectRAge 0.90 2.0E-30*
Skin & blood clock 0.87 3.5E-26*
GrimAge 0.85 1.1E-23*
GrimAge2 0.84 2.7E-22*
Multi-tissue clock 0.81 1.6E-19*
KDM 0.76 2.2E-16*
ProtAge-MD 0.67 2.2E-16*
PhenoAge 0.66 3.8E-11*
Hannum clock 0.65 4.8E-11*
ProtAge-Tanaka 0.60 2.2E-16*
MetaClock 0.56 8.7E-08*
PCA-Levine 0.48 2.2E-16*
MLR-Levine 0.40 1.4E-15*
ClinAge-MD 0.37 1.2E-13*
EpiTOC 0.25 2.4E-02*
MiAge 0.20 7.6E-02
MetaboAge-vdA 0.18 8.6E-03*
mPoA 0.18 1.1E-01
DunedinPACE 0.15 1.7E-01
MetaboAge-MD 0.08 2.6E-01
EpiTOC2 0.04 7.4E-01
CausAge 0.69 1.8E-12*
DamAge 0.62 1.3E-09*
AdaptAge 0.49 3.6E-06*

*Significant correlations are displayed with an asterisk (at p < 0.05). GrimAge and KDM incorporate chronological age in their calculation.