Table 2.

Data collection of the IAM Frontier study

Data	Measurement technique	Timepoints – month	Type of sample	Total samples	Remarks
DNA methylation	Illumina Infinium MethylationEPIC BeadChips	2-8-13	PBMC	96	20 samples at month 13, 16 technical replicates
Clinical and physiological	Clinical biochemistry, blood cell counts, health examination	1-2-3-4-5-6-7-8-9-10-11-12-13	Whole blood, serum PB, fasting urine	380	20 samples at month 13
Metabolomics	NMR - MS	1-3-5-7-9-11-13	Plasma	200
Proteomics	LC-MSMS -PEA	1-3-5-7-9-11-13	Plasma	200
Microbiome	Illumina MiSeq	1-6-13	Stool	20	16 samples at month 13